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BIOTAGE mplc-system biotage isolera prime 3.0
Mplc System Biotage Isolera Prime 3.0, supplied by BIOTAGE, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/biotage+isolera+prime/mplc++biotage+isolera++25+g+snap+cartridge+/pmc10091970__CHEM___28___0___s001-31-31-32
Average 90 stars, based on 1 article reviews
mplc-system biotage isolera prime 3.0 - by Bioz Stars, 2026-10
90/100 stars

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Related Articles

Irradiation:

Article Title: Deconstruction of Desacetamidocolchicine’s B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties
Article Snippet: The resulting oil was purified by chromatography (Biotage Isolera Prime, SiliCycle Silia Sep 40 g silica gel, 40–63 μm 60 Å, solvent gradient: 0–100% EtOAc in hexanes (500 mL) and concentrated to reveal 14 as a pale yellow solid (3.2 g, 96% yield). m.p.

Article Title: Deconstruction of Desacetamidocolchicine’s B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties
Article Snippet: The reaction was subjected to microwave irradiation at 120 °C–150 °C for 1 to 10 h. The resulting solution was immediately subjected to purification via column chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 10 g silica gel, 40–63 μm 60 Å, solvent gradient: 0–100% EtOAc in hexanes [500 mL]).

Article Title: Deconstruction of Desacetamidocolchicine's B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties.
Article Snippet: The resulting oil was purified by chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 40 g silica gel, 40−63 μm 60 Å, solvent gradient: 0−100% EtOAc in hexanes (500 mL) and concentrated to reveal 14 as a pale yellow solid (3.2 g, 96% yield). m.p.

Article Title: Deconstruction of Desacetamidocolchicine’s B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties
Article Snippet: The resulting oil was then purified by chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 10 g silica gel, 40–63 μm 60 Å, solvent gradient: 0–100% acetonitrile in dichloromethane [500 mL]).

Article Title: Deconstruction of Desacetamidocolchicine's B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties.
Article Snippet: The resulting oil was then purified by chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 10 g silica gel, 40−63 μm 60 Å, solvent gradient: 0−100% acetonitrile in dichloromethane [500 mL]).

Article Title: Deconstruction of Desacetamidocolchicine's B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties.
Article Snippet: The reaction was subjected to microwave irradiation at 120 °C−150 °C for 1 to 10 h. The resulting solution was immediately subjected to purification via column chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 10 g silica gel, 40−63 μm 60 Å, solvent gradient: 0− 100% EtOAc in hexanes [500 mL]). (±)-(1S,5S)-3-methoxy-6-(2,3,4-trimethoxy-6-methylphenyl)-8oxabicyclo[3.2.1]octa-3,6-dien-2-one (17).

Article Title: Deconstruction of Desacetamidocolchicine's B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties.
Article Snippet: The mixture was then diluted with deionized water, extracted with Et2O (5×), and the combined organics washed with Rochelle’s salt (3×), water (1×), and brine (1×), then dried with Na2SO4, filtered, concentrated, and then purified via chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 40 g silica gel, 40−63 μm 60 Å, solvent gradient: 0−100% acetonitrile in dichloromethane).

Purification:

Article Title: Deconstruction of Desacetamidocolchicine’s B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties
Article Snippet: The resulting oil was purified by chromatography (Biotage Isolera Prime, SiliCycle Silia Sep 40 g silica gel, 40–63 μm 60 Å, solvent gradient: 0–100% EtOAc in hexanes (500 mL) and concentrated to reveal 14 as a pale yellow solid (3.2 g, 96% yield). m.p.

Article Title: Deconstruction of Desacetamidocolchicine’s B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties
Article Snippet: The reaction was subjected to microwave irradiation at 120 °C–150 °C for 1 to 10 h. The resulting solution was immediately subjected to purification via column chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 10 g silica gel, 40–63 μm 60 Å, solvent gradient: 0–100% EtOAc in hexanes [500 mL]).

Article Title: Deconstruction of Desacetamidocolchicine's B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties.
Article Snippet: The resulting oil was purified by chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 40 g silica gel, 40−63 μm 60 Å, solvent gradient: 0−100% EtOAc in hexanes (500 mL) and concentrated to reveal 14 as a pale yellow solid (3.2 g, 96% yield). m.p.

Article Title: Deconstruction of Desacetamidocolchicine’s B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties
Article Snippet: The resulting oil was then purified by chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 10 g silica gel, 40–63 μm 60 Å, solvent gradient: 0–100% acetonitrile in dichloromethane [500 mL]).

Article Title: Deconstruction of Desacetamidocolchicine's B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties.
Article Snippet: The resulting oil was then purified by chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 10 g silica gel, 40−63 μm 60 Å, solvent gradient: 0−100% acetonitrile in dichloromethane [500 mL]).

Article Title: Deconstruction of Desacetamidocolchicine's B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties.
Article Snippet: The reaction was subjected to microwave irradiation at 120 °C−150 °C for 1 to 10 h. The resulting solution was immediately subjected to purification via column chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 10 g silica gel, 40−63 μm 60 Å, solvent gradient: 0− 100% EtOAc in hexanes [500 mL]). (±)-(1S,5S)-3-methoxy-6-(2,3,4-trimethoxy-6-methylphenyl)-8oxabicyclo[3.2.1]octa-3,6-dien-2-one (17).

Article Title: Deconstruction of Desacetamidocolchicine's B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties.
Article Snippet: The mixture was then diluted with deionized water, extracted with Et2O (5×), and the combined organics washed with Rochelle’s salt (3×), water (1×), and brine (1×), then dried with Na2SO4, filtered, concentrated, and then purified via chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 40 g silica gel, 40−63 μm 60 Å, solvent gradient: 0−100% acetonitrile in dichloromethane).

Column Chromatography:

Article Title: Deconstruction of Desacetamidocolchicine’s B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties
Article Snippet: The resulting oil was purified by chromatography (Biotage Isolera Prime, SiliCycle Silia Sep 40 g silica gel, 40–63 μm 60 Å, solvent gradient: 0–100% EtOAc in hexanes (500 mL) and concentrated to reveal 14 as a pale yellow solid (3.2 g, 96% yield). m.p.

Article Title: Deconstruction of Desacetamidocolchicine’s B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties
Article Snippet: The reaction was subjected to microwave irradiation at 120 °C–150 °C for 1 to 10 h. The resulting solution was immediately subjected to purification via column chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 10 g silica gel, 40–63 μm 60 Å, solvent gradient: 0–100% EtOAc in hexanes [500 mL]).

Article Title: Deconstruction of Desacetamidocolchicine's B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties.
Article Snippet: The resulting oil was purified by chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 40 g silica gel, 40−63 μm 60 Å, solvent gradient: 0−100% EtOAc in hexanes (500 mL) and concentrated to reveal 14 as a pale yellow solid (3.2 g, 96% yield). m.p.

Article Title: Deconstruction of Desacetamidocolchicine’s B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties
Article Snippet: The resulting oil was then purified by chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 10 g silica gel, 40–63 μm 60 Å, solvent gradient: 0–100% acetonitrile in dichloromethane [500 mL]).

Article Title: Deconstruction of Desacetamidocolchicine's B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties.
Article Snippet: The resulting oil was then purified by chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 10 g silica gel, 40−63 μm 60 Å, solvent gradient: 0−100% acetonitrile in dichloromethane [500 mL]).

Article Title: Deconstruction of Desacetamidocolchicine's B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties.
Article Snippet: The reaction was subjected to microwave irradiation at 120 °C−150 °C for 1 to 10 h. The resulting solution was immediately subjected to purification via column chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 10 g silica gel, 40−63 μm 60 Å, solvent gradient: 0− 100% EtOAc in hexanes [500 mL]). (±)-(1S,5S)-3-methoxy-6-(2,3,4-trimethoxy-6-methylphenyl)-8oxabicyclo[3.2.1]octa-3,6-dien-2-one (17).

Article Title: Deconstruction of Desacetamidocolchicine's B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties.
Article Snippet: The mixture was then diluted with deionized water, extracted with Et2O (5×), and the combined organics washed with Rochelle’s salt (3×), water (1×), and brine (1×), then dried with Na2SO4, filtered, concentrated, and then purified via chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 40 g silica gel, 40−63 μm 60 Å, solvent gradient: 0−100% acetonitrile in dichloromethane).

Solvent:

Article Title: Deconstruction of Desacetamidocolchicine’s B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties
Article Snippet: The resulting oil was purified by chromatography (Biotage Isolera Prime, SiliCycle Silia Sep 40 g silica gel, 40–63 μm 60 Å, solvent gradient: 0–100% EtOAc in hexanes (500 mL) and concentrated to reveal 14 as a pale yellow solid (3.2 g, 96% yield). m.p.

Article Title: Deconstruction of Desacetamidocolchicine’s B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties
Article Snippet: The reaction was subjected to microwave irradiation at 120 °C–150 °C for 1 to 10 h. The resulting solution was immediately subjected to purification via column chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 10 g silica gel, 40–63 μm 60 Å, solvent gradient: 0–100% EtOAc in hexanes [500 mL]).

Article Title: Deconstruction of Desacetamidocolchicine's B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties.
Article Snippet: The resulting oil was purified by chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 40 g silica gel, 40−63 μm 60 Å, solvent gradient: 0−100% EtOAc in hexanes (500 mL) and concentrated to reveal 14 as a pale yellow solid (3.2 g, 96% yield). m.p.

Article Title: Deconstruction of Desacetamidocolchicine’s B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties
Article Snippet: The resulting oil was then purified by chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 10 g silica gel, 40–63 μm 60 Å, solvent gradient: 0–100% acetonitrile in dichloromethane [500 mL]).

Article Title: Deconstruction of Desacetamidocolchicine's B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties.
Article Snippet: The resulting oil was then purified by chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 10 g silica gel, 40−63 μm 60 Å, solvent gradient: 0−100% acetonitrile in dichloromethane [500 mL]).

Article Title: Deconstruction of Desacetamidocolchicine's B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties.
Article Snippet: The reaction was subjected to microwave irradiation at 120 °C−150 °C for 1 to 10 h. The resulting solution was immediately subjected to purification via column chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 10 g silica gel, 40−63 μm 60 Å, solvent gradient: 0− 100% EtOAc in hexanes [500 mL]). (±)-(1S,5S)-3-methoxy-6-(2,3,4-trimethoxy-6-methylphenyl)-8oxabicyclo[3.2.1]octa-3,6-dien-2-one (17).

Article Title: Deconstruction of Desacetamidocolchicine's B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties.
Article Snippet: The mixture was then diluted with deionized water, extracted with Et2O (5×), and the combined organics washed with Rochelle’s salt (3×), water (1×), and brine (1×), then dried with Na2SO4, filtered, concentrated, and then purified via chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 40 g silica gel, 40−63 μm 60 Å, solvent gradient: 0−100% acetonitrile in dichloromethane).

Chromatography:

Article Title: Deconstruction of Desacetamidocolchicine’s B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties
Article Snippet: The resulting oil was purified by chromatography (Biotage Isolera Prime, SiliCycle Silia Sep 40 g silica gel, 40–63 μm 60 Å, solvent gradient: 0–100% EtOAc in hexanes (500 mL) and concentrated to reveal 14 as a pale yellow solid (3.2 g, 96% yield). m.p.

Article Title: Deconstruction of Desacetamidocolchicine’s B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties
Article Snippet: The reaction was subjected to microwave irradiation at 120 °C–150 °C for 1 to 10 h. The resulting solution was immediately subjected to purification via column chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 10 g silica gel, 40–63 μm 60 Å, solvent gradient: 0–100% EtOAc in hexanes [500 mL]).

Article Title: Deconstruction of Desacetamidocolchicine's B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties.
Article Snippet: The resulting oil was purified by chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 40 g silica gel, 40−63 μm 60 Å, solvent gradient: 0−100% EtOAc in hexanes (500 mL) and concentrated to reveal 14 as a pale yellow solid (3.2 g, 96% yield). m.p.

Article Title: Deconstruction of Desacetamidocolchicine’s B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties
Article Snippet: The resulting oil was then purified by chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 10 g silica gel, 40–63 μm 60 Å, solvent gradient: 0–100% acetonitrile in dichloromethane [500 mL]).

Article Title: Deconstruction of Desacetamidocolchicine's B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties.
Article Snippet: The resulting oil was then purified by chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 10 g silica gel, 40−63 μm 60 Å, solvent gradient: 0−100% acetonitrile in dichloromethane [500 mL]).

Article Title: Deconstruction of Desacetamidocolchicine's B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties.
Article Snippet: The reaction was subjected to microwave irradiation at 120 °C−150 °C for 1 to 10 h. The resulting solution was immediately subjected to purification via column chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 10 g silica gel, 40−63 μm 60 Å, solvent gradient: 0− 100% EtOAc in hexanes [500 mL]). (±)-(1S,5S)-3-methoxy-6-(2,3,4-trimethoxy-6-methylphenyl)-8oxabicyclo[3.2.1]octa-3,6-dien-2-one (17).

Article Title: Deconstruction of Desacetamidocolchicine's B Ring Reveals a Class 3 Atropisomeric AC Ring with Tubulin Binding Properties.
Article Snippet: The mixture was then diluted with deionized water, extracted with Et2O (5×), and the combined organics washed with Rochelle’s salt (3×), water (1×), and brine (1×), then dried with Na2SO4, filtered, concentrated, and then purified via chromatography (Biotage Isolera Prime, SiliCycle SiliaSep 40 g silica gel, 40−63 μm 60 Å, solvent gradient: 0−100% acetonitrile in dichloromethane).



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